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This is How to Turn Back the Clock on Aging

For the first time ever, a randomized, controlled clinical trial has demonstrated the ability to reverse biological age

Andrew Merle
8 min readSep 28, 2020


People have been searching for the fountain of youth throughout history.

Now we have scientific data that shows you can turn back the clock on aging.

For the first time, a randomized, controlled clinical trial has demonstrated the reversal of biological age. This trial also marks the first time a diet and lifestyle intervention has been proven to reduce biologic aging.

In just 8 short weeks, those in the ‘treatment’ group (18 people) of the study tested an average of 1.96 years younger, according to the Horvath DNA methylation age and epigenetic clock.

We now have scientific ‘clocks’ that measure markers of age with remarkable accuracy and the best of these is the Horvath DNAmAge clock. The Horvath clock is a multi-tissue predictor of age that estimates the DNA methylation age of most tissues and cell types.

Horvath’s DNAmAge clock has actually been shown to predict all-cause mortality better than chronological age.

Getting nearly 2 years younger after just 8 weeks is pretty impressive. But how about the control group of 20 people who didn’t undergo any diet or lifestyle changes? They got an average of 1.27 years older at the end of the study compared to the beginning.

So that means the people in the treatment group were actually 3.23 years younger than the participants in the control group after just 8 weeks.

Participants in the treatment group also had significant improvements in triglycerides, cholesterol levels, and serum methyl folate. Their mood improved as well.

It is important to keep in mind that this trial had a relatively small sample size and the published report is still in preprint (not yet peer reviewed). But the results are striking nonetheless.

What exactly was this magical intervention?

It focused on just 4 basic, common-sense pillars of health: Diet, Exercise, Sleep, and Stress Management.



Andrew Merle

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